Most First Nations ethnology collections found in Canadian museums today were gathered (and sometimes confiscated) by missionaries, government agents, amateur and professional collectors and anthropologists such as Edward Sapir and Marius Barbeau during the late 1800s and early 1900s. At that time, Indigenous culture was believed to be dying out. These collections, which include thousands of everyday artifacts, ceremonial and sacred objects, ancestral skeletal remains and funerary objects, were intended to allow future generations of anthropologists and students to study traditional Indigenous cultures. Aboriginal people now say they are alienated from the materials of their past heritage that are housed in the Canadian Museum of History and various provincial museums such as the Royal Ontario Museum, Glenbow Museum and the University of British Columbia Museum of Anthropology. Many groups are requesting that these items be returned to their people.

Though no Canadian legislation exists to implement repatriation, museums currently consider First Nations' requests on a case-by-case basis. Legality of ownership and communal ceremonial significance, as well as the physical condition or state of preservation of the objects, are taken into consideration. Sometimes repatriation is not practical, as when communities lack facilities or trained personnel in the management, care or use of materials. Museums may act as caretakers of collections on behalf of their traditional owners.

Examples of successful claims to objects in the Canadian Museum of Civilization include the return of confiscated potlatch items to the Alert Bay and Cape Mudge peoples in 1978, the Starlight medicine bundle to the Tsuut’ina (Sarcee) people of Alberta in 1989, and the 1991 return to the Six Nations Confederacy of three wampum belts (the Circlet of the League, the Mohawk Chief's wampum, and a Seneca wampum called The Three Sisters). In 2001, the museum adopted a written policy on repatriation (see Museum Policy). Several other museums across the country also have, or are developing repatriation guidelines or policies.

The topic of artifact repatriation is now commonly addressed in Canadian land claims. These agreements usually outline government responsibilities for helping First Nations to repatriate artifacts to their areas. The Nisga'a agreement (1999) was the first to include major provisions for repatriation. The Nisga'a have negotiated the repatriation of 200 artifacts from the Canadian Museum of Civilization and the Royal British Columbia Museum. The Labrador Inuit Land Claims Agreement (2005) also provides for the repatriation of nearly 80 artifacts from the Canadian Museum of Civilization. Several First Nations are establishing their own facilities for the safekeeping and exhibition of repatriated objects.